To carry on business or trade.To treat with another or others, as in the arrangement of a treaty, or in preliminaries to the transaction of any business; carry on negotiations.To arrange for or procure by negotiation; bring about by mutual arrangement, a discussion, or bargaining; as, to negotiate a loan or a treaty.To direct; manage; transact.To handle; manage.To put, into circulation by transference and assignment of claim by indorsement: as, to negotiate a bill of exchange.To dispose of by sale or transfer: as, to negotiate securities.