n. A non-glandular, highly vascular organ which is situated in the abdomen, on the left side, in connection with the digestive organs, and in which the blood undergoes certain modifications in respect of its corpuscles.n. Ill humor; melancholy; low spirits.n. Bad temper; anger; ill-will; malice; latent spite; grudge: as, to vent one's spleen; a fit of the spleen.n. A sudden impulse, fancy, or caprice; a whim.n. Mood; disposition.To deprive of the spleen; extirpate the spleen of.To anger; annoy.To dislike; hate.To have a loathing; become disgusted.