What does cytoplasmically mean?
“Cytoplasmically” is a specialized adverb meaning in the cytoplasm, the gel-like material surrounding a cell’s nucleus. It is most often used in cell and molecular biology when describing the location, movement, distribution, or confinement of a substance within a cell. For example, a protein may be described as cytoplasmically localized, while a signal may spread cytoplasmically through the cell. The term is precise but uncommon in general writing; in less technical contexts, “in the cytoplasm” or “within the cytoplasm” is usually clearer. It should not be confused with “intracellularly,” which means anywhere inside a cell, including the nucleus, or with “extracellularly,” which means outside the cell. Although the word sounds elaborate, it simply adds adverbial force to “cytoplasmic,” making it useful whenever a statement needs to specify not merely that something is cellular, but exactly where within the cell it is situated or acting.
adverbIn, within, or with respect to the cytoplasm of a cell.
- In, within, or with respect to the cytoplasm of a cell.
"The signaling protein moved cytoplasmically through the cell."
"The reporter was distributed cytoplasmically throughout the cell."
"This regulator acts cytoplasmically rather than within the nucleus."
When a biologist says something happens cytoplasmically, it happens inside the cell’s working fluid—not in the nucleus.
Reviewed by Deb Chak, Editor. AI-assisted content curated by RJS Tech Solutions LLP.
Where does cytoplasmically come from?
Cytoplasmically is formed adverbially from cytoplasmic, the adjectival form of cytoplasm, using the suffix “-ally.” Cytoplasm combines Greek kytos, meaning “cell,” with plasma, meaning “formation” or “something molded,” reflecting its historical sense of the cell’s formed material. The related adjective “cytoplasmatic” is also encountered, although “cytoplasmic” is now the standard modern form.
How cytoplasmically is actually used
Predominantly used in cell biology, molecular biology, and biochemistry. In general writing, “in the cytoplasm” is usually clearer and more natural.
Easily confused with cytoplasmically
“Cytoplasmic” is an adjective describing something located in or associated with the cytoplasm, whereas “cytoplasmically” is an adverb describing an action or condition occurring there.